Targeting the Wnt pathway in cancer
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Publication
2011 - Springer, New York, New York (State)
Language
English
Word Count
60,000 words, Guess
Page Count
240 pages
Identifiers
- Open LibraryOL25021819M
- ISBN-139781441980229
- ISBN-101441980229
- OCLC Control Number720560332
- Library of Congress Control Number2011920692
Classifications
- LCCRC271.G45 T37 2011
- LCCRC254-282RM1-950RC26
- LCCRC254-282
Description
Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
Subjects
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