Microdialysis In Drug Development
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Author
Publication
2012 - Springer
Word Count
84,500 words, Guess
Page Count
338 pages
Identifiers
- Open LibraryOL25977859M
- ISBN-139781461448143
- Library of Congress Control Number2012947069
Classifications
- LCCRM301.25 .M54 2013
Description
In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.
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